Bortezomib for Refractory Immune-Mediated Thrombocytopenia Purpura
نویسندگان
چکیده
منابع مشابه
Drug-induced immune-mediated thrombocytopenia--from purpura to thrombosis.
891 I 1949, Ackroyd reported the abrupt onset of severe thrombocytopenia and purpura in patients receiving the sedative allylisopropylacetylcarbamide (Sedormid).1 All the patients had taken Sedormid previously and had become sensitized to it. Today, this classic picture of drug-induced, immunemediated thrombocytopenia is most often caused by quinine in outpatients and by vancomycin in hospitali...
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Laparoscopic splenectomy (LS) for immune thrombocytopenic purpura has a success rate of 70-90%. This invasive procedure is sometimes required for patients with refractory thrombocytopenia. However, no data on their outcome are available. If the hematologic response is inadequate, its value vis-à-vis the risk associated with major surgery is open to question. Twelve of 110 patients who underwent...
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A minority or children with idiopathic or immune thrombocytopenic purpura (ITP) have the rerractory chronic rorm with bleeding problems (stage III or IV). The aim or this article is to provide an update on the immunopathogenesis and management or children with bleeding and severe refractory lIP. The man~lgement of such patients. according to a st~lging guideline. is described. I{ecent ciinic~11...
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Thrombocytopenia is defined as a platelet count of less than 100,000 platelets per microlitre (mcL). Thrombocytopenia develops in approximately 6-7% of women during pregnancy and at least 3% of these cases are caused by immunological platelet destruction. Herein, we present a pregnant woman who develops at the first trimester autoimmune thrombocytopenia purpura associated with positive antiphos...
متن کاملHow I treat refractory immune thrombocytopenia.
This article summarizes our approach to the management of children and adults with primary immune thrombocytopenia (ITP) who do not respond to, cannot tolerate, or are unwilling to undergo splenectomy. We begin with a critical reassessment of the diagnosis and a deliberate attempt to exclude nonautoimmune causes of thrombocytopenia and secondary ITP. For patients in whom the diagnosis is affirm...
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ژورنال
عنوان ژورنال: American Journal of Therapeutics
سال: 2018
ISSN: 1075-2765
DOI: 10.1097/mjt.0000000000000517